ESPN 54th Annual Meeting

ESPN 2022


 
PRETERM BIRTH: IS IT A RISK FACTOR FOR HYPERTENSION AND REDUCED KIDNEY VOLUME?
Ozge Oguzhan 1 AYSE AGBAS 2 SEHA SAYGILI 2 NAZLI GULSUM AKYEL 3 KUBRA YILMAZ 1 SEBUH KURUGOGLU 3 DILDAR KONUKOGLU 4 NUR CANPOLAT 2 SALIM CALISKAN 2 LALE SEVER 2

1- ISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPASA FACULTY OF MEDICINE, DEPARTMENT OF PEDIATRICS, ISTANBUL, TURKEY
2- ISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPASA FACULTY OF MEDICINE, DEPARTMENT OF PEDIATRIC NEPHROLOGY, ISTANBUL, TURKEY
3- ISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPASA FACULTY OF MEDICINE, DEPARTMENT OF PEDIATRIC RADIOLOGY, ISTANBUL, TURKEY
4- ISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPASA FACULTY OF MEDICINE, DEPARTMENT OF MEDICAL BIOCHEMISTRY, ISTANBUL, TURKEY
 
Introduction:

 The aim of this study is to evaluate the kidney volume and its relationship with kidney function and blood pressure (BP) in children born prematurely with low birth weight.

Material and methods:

 This cross-sectional observational case-control study included 50 preterm-born children (mean age 11.5±1.9 years, 58 % female) with low birth weight (preterm group) and 27 term-born children (control group). The preterm group was divided into subgroups according to birth weight and gestational age, as small and appropriate for gestational age, SGA and AGA groups, respectively. Estimated glomerular filtration rate (eGFR, by Zappitelli formula using creatinine and cystatin C) and microalbuminuria (urine albumin-to-creatinine ratio) were assessed. Blood pressure (office and 24-hour ambulatory blood pressure monitoring) and kidney volume measurements (ultrasound, USG and magnetic resonance imaging, MRI) were performed. Kidney volumes were adjusted by body surface area and expressed as total kidney volume index; USG-TKVi and MRI-TKVi, respectively.

Results:

 The median USG-TKVi of the preterm group was smaller than the control group [131 (115;143) cm3/m2 vs 143 (127;159) cm3/m2, respectively, p=0.036]; however, the MR-TKVi was not significantly different between the two groups. There was no difference in eGFR, BP-SDSs between preterm and control groups. In univariate analysis, both USG- and MRI-TKVi were positively correlated with birth weight-SDS (p=0.027, r=0.312 and p=0.040, r=0.292, respectively) and MRI-TKVi was also correlated with eGFR (p=0.008, r=0.373), but there was no correlation with gestational week or BP-SDSs. In the subgroup analysis, the SGA group (n=16) had significantly lower median USG-TKVi [119 (110;130) cm3/m2 vs 136 (124;146) cm3/m2, respectively, p=0.017] and MRI-TKVi [109 (103;123) cm3/m2 vs 123 (115;139) cm3/m2, respectively, p=0.022)] compared to the AGA group (n=34), but the BP-SDs were not different.

Conclusions:

 Preterm-born children, especially who were SGA, have lower kidney volume compared to healthy counterparts. Therefore, long-term follow up of these children is important.