ESPN 54th Annual Meeting

ESPN 2022


 
The italian registry of thrombosis in children (RITI): potential and perspectives.
DAVIDE MENEGHESSO 1 ALESSIA CICOGNA 1 CHIARA GUARIENTO 1 JACOPO NORBERTO PIN 1 CLARISSA TONA 1 MARIA FEDERICA PELIZZA 1 ANDREA FRANCAVILLA 3 GIULIA LORENZONI 3 MATTEO MARTINATO 3 ROSSANA BAGNA 4 LAURA ILARDI 5 DONATELLA LASAGNI 6 MATTEO LUCIANI 7 MARGHERITA NOSADINI 2 ANNA ROSATI 6 PAOLA SARACCO 4 AGNESE SUPPIEJ 8 MARIA CATERINA PIUTTI 9 DARIO GREGORI 3 STEFANO SARTORI 2 PAOLO SIMIONI 10

1- PEDIATRIC NEPHROLOGY - UNIVERSITY OF PADUA
2- PEDIATRIC NEUROLOGY - UNIVERSITY OF PADUA
3- DEPARTMENT OF CARDIO-THORACO-VASCULAR SCIENCES AND PUBLIC HEALTH, UNIVERSITY OF PADUA
4- UNIVERSITY OF TURIN
5- NEONATOLOGY, MILAN NIGUARDA HOSPITAL
6- MEYER, PEDIATRIC HOSPITAL
7- PEDIATRIC ONCO-HEMATOLOGY, PEDIATRIC HOSPITAL BAMBINO GESù, ROME
8- PEDIATRIC NEUROLOGY, UNIVERSITY OF FERRARA
9- PEDIATRIC ONCO-HEMATOLOGY, UNIVERSITY OF PADUA
10- THROMBOTIC AND HAEMORRHAGIC DISEASES UNIT, DEPARTMENT OF MEDICINE - DIMED, UNIVERSITY OF PADUA
 
Introduction:

Patients with kidney disease (KD) may present an increased risk of thrombotic events due to renal failure, vascular catheterization and medical therapies. In the last decades national and international registries have been created to implement the knowledge around thrombosis in children. The Italian registry of thrombosis in children (R.I.T.I.) was founded in 2007 with the contribution of hematologists, pediatricians, pediatric neurologists and emergency care physicians. Its aim is to collect information nationwide about pediatric and neonatal thrombosis. Starting in 2017, an observational study was designed with the following objectives: i) multiparametric definition of thrombosis in children; ii) development of diagnostic and therapeutic protocols; iii) implementation of a multidisciplinary network (including pediatric nephrologists and oncohemalogists).

Material and methods:

Since 2017 clinical, instrumental and laboratoristic findings of pediatric patients affected by thrombosis were systematically collected together with the characteristics of the thrombotic events and follow up data.

Results:

To date, 49 italian hospitals and 121 physicians are contributing to the registry. 727 patients have been included(57%males). Of them, 502(69%) had cerebral thrombosis (68%arterial) while 225(31%) had systemic thrombosis (85%venous). The majority of the included patients(51%) had an event at pre-school age. In the evaluated time period, recurrencies were most frequently observed in pediatric patients(9%) than in newborns(3.5%). 66(9%) patients included in the registry were affected by KD. Of them, 31% had cerebral thrombosis and 69% systemic thrombosis. The nephrologic diagnosis was: AKI(n=22); nephrotic syndrome(n=5); CKD(n=5); dialysis(n=23); miscellaneous(n=18).

 

Conclusions:

The progressive implementation of R.I.T.I. from 2007 to date makes it one of the largest registries about children thrombosis internationally. Further collaborations with national and international nephrologic centres are warrented in order to enlarge the knowledge around pediatric thrombosis in patients affected by KD.