ESPN 54th Annual Meeting

ESPN 2022


 
EPIDEMIOLOGY OF INS DURING COVID PANDEMIC COMPARED TO THE LAST DECADE : A REGIONWIDE RETROSPECTIVE STUDY IN THE PARIS AREA
VICTOIRE THENOT 1 CYRIELLE PARMENTIER 2 OLIVIA BOYER 3 FOUAD MADHI 4 SYLVIE NATHANSON 5 FERIELLE ZENKHRI 6 PHILIPPE BLANC 1 NASSER MENDLI 8 AURELIEN GALERNE 9 ALEXIS MANDELCWAJG 10 JULIEN HOGAN 1 CLAIRE DOSSIER 1

1- PEDIATRIC NEPHROLOGY, ROBERT-DEBRE HOSPITAL, PARIS, APHP
2- PEDIATRIC NEPHROLOGY, ARMAND-TROUSSEAU HOSPITAL, PARIS, APHP
3- PEDIATRIC NEPHROLOGY, NECKER HOSPITAL, PARIS, APHP
4- DEPARTMENT OF PEDIATRICS, CHI CRETEIL
5- DEPARTMENT OF PEDIATRICS, CH DE VERSAILLES, LE CHESNAY
6- DEPARTMENT OF PEDIATRICS, BICETRE HOSPITAL, KREMLIN-BICETRE, APHP
7- DEPARTMENT OF PEDIATRICS, CH POISSY
8- DEPARTMENT OF PEDIATRICS, CH GONESSE
9- DEPARTMENT OF PEDIATRICS, JEAN-VERDIER HOSPITAL, BONDY, APHP
10- DEPARTMENT OF PEDIATRICS, CH DE SAINT-DENIS
 
Introduction:

 The etiology of idiopathic nephrotic syndrome (INS) remains partially unknown. Viral infections have been reported associated to INS onset. Thus, both SARS-CoV-2 infection and lockdown measures may have influenced INS incidence. The aim of this study was to describe the incidence of childhood INS during the COVID19 pandemic and  compare it to the pre-COVID period.  

Material and methods:

 A written questionnaire was sent to the 37 pediatric departments in Paris area. Children aged 1 to 15 years, living in the Paris area, with INS onset between January 2017 and December 2020 were included. To estimate incidence, population-based denominators were obtained from the National Institute for Statistics and Economic Studies (INSEE). Data were compared to the NEPHROVIR cohort over the 2008-2013 period. 

Results:

 Between 2007 and 2020, 248 cases of INS were reported. Median age was 5.6 years, M/F ratio 2.1/1 and 94 % were steroid sensitive. Annual incidences were 2.66, 2.49, 2.91 and 2.40 per 100 000 children aged 15 years for 2017, 2018, 2019, 2020 respectively, with no significant difference between years and also no difference with the 2008-2013 period. During the lockdown measures (2months), incidence was 0.76 versus 2.71 for the rest of the study period (46 months) (p < 0.05). During week 15 (6-12 April 2020), with the peak of hospital admissions for COVID-19, no case of INS was reported.  

Conclusions:

 Over the last decade, incidence of childhood INS was stable in the Paris area. In 2020, no peak of incidence occurred concomitantly to COVID pandemic. In addition, during lockdown measures, incidence of INS was significantly lower. Interestingly, incidence of other respiratory viral infections were reported reduced during lockdown measures. Together, these results argue again for a link between INS onset and viral infections, while COVID-19 does not appear to be a significative trigger for INS onset in children.