ESPN 54th Annual Meeting

ESPN 2022


 
PRETERM BIRTH, HYPERTENSION AND ARTERIAL STIFFNESS IN CHILDREN AND ADOLESCENTS
ATHANASIA CHAINOGLOU 1 KOSMAS SARAFIDIS 2 KATERINA CHRYSAIDOU 1 EVANGELIA FARMAKI 1 KONSTANTINOS KOLLIOS 3 MARINA ECONOMOU 1 VASILIOS KOTSIS 4 STELLA STABOULI 1

1- 1ST DEPARTMENT OF PEDIATRICS, GENERAL HOSPITAL OF THESSALONIKI "HIPPOKRATIO", GREECE
2- 1ST DEPARTMENT OF NEONATOLOGY, GENARAL HOSPITAL OF THESSALONIKI "HIPPOKRATIO", GREECE
3- 3RD DEPARTMENT OF PEDIATRICS, GENERAL HOSPITAL OF THESSALONIKI "HIPPOKRATIO", GREECE
4- 3RD DEPARTMENT OF INTERNAL MEDICINE, GENERAL HOSPITAL OF THESSALONIKI "PAPAGEORGIOU", GREECE
 
Introduction:

According to the recent literature, preterm birth is associated with increased risk of developing chronic kidney disease and arterial hypertension in future life. The aim of the current study was to investigate the association between preterm birth and ambulatory blood pressure (BP) levels and arterial stiffness during childhood and adolescence.

Material and methods:

The sample of this prospective case control study included 52 children and adolescents born preterm and 26 children born full-term. All of  the participants underwent measurement of somatometric characteristics, office BP, central systolic BP, ambulatory BP monitoring (ABPM) and assessment of carotid-femoral pulse wave velocity (PWV).

Results:

Overall, in the study participated 52 preterm with mean age 10,4±3,8 years and 22 full-term children with mean age 11,2±3,2 years. Preterm children presented significantly higher night systolic blood pressure (SBP) z score values compared to controls (p<0.05). Preterm children who were overweight/obese presented significantly higher values of night SBP compared to other subgroups. Preterm children also presented marginally higher PWV z score values (p=0.06).  Predictors of night SBP z score were preterm birth and BMI z score, whereas prematurity was an independent predictor of PWV z score.

Conclusions:

Our study’s findings support that preterm birth is associated with higher nocturnal BP and increased arterial stiffness in childhood and adolescence. The early diagnosis of hypertension and the prevention of obesity during childhood are important in the prevention of future adverse health outcomes in individuals born preterm.