ESPN 54th Annual Meeting

ESPN 2022


 
EVALUATION OF TRACE ELEMENT LEVELS IN CHRONIC KIDNEY PATIENTS IN CHILDHOOD
ALI MURATOĞLU 1 BELTİNGE DEMIRCIOĞLU KILIÇ 2 MEHTAP AKBALIK KARA 2 SEYITHAN TAYSI 3 MITHAT BÜYÜKÇELIK 2 AYŞE BALAT 2

1- HATAY EDUCATION AND RESEARCH HOSPITAL, DEPARTMENT OF PEDIATRICS, HATAY/TURKEY
2- GAZIANTEP UNIVERSITY, DEPARTMENT OF PEDIATRIC NEPHROLOGY, GAZIANTEP/TURKEY
3- GAZIANTEP UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF MEDICAL BIOCHEMISTRY, GAZIANTEP, TURKEY
 
Introduction:

Trace elements are found in very low concentrations in biological fluids or tissues, which can sometimes cause deficiency and toxicity in chronic kidney disease (CKD) patients. In our study, we aimed to evaluate trace element levels in childhood CKD.

Material and methods:

Children who were diagnosed as CKD (n:64) with GFR below 60 ml/min/1.73 m2 and healthy children (n:25) were included in the study. Patients with CKD were divided into stage 3-4 CKD (n:27), haemodialysis (HD) (n:12) and peritoneal dialysis (PD) (n:25) groups. Zinc (Zn) and copper (Cu) were measured in serum with a fully automatic biochemistry autoanalizer. Selenium (Se), manganese (Mn), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni) were measured by inductively coupled plasma optical emission spectrometry (ICP-OES) method.

Results:

Serum Cu median value ; In the control group, 178 µg/dl (135.2-270.3); In stage 3-4 CKD patients, 129.4 µg/dl (108.6-139.1); In HD patients, 106.35 µg/dl (96.25-130.5); In PD patients, 135.4 µg/dl (122.5-144.4) was detected. Copper level was found higher in the control group compared to the patient groups, and this difference was significant (p=0.001). Serum Cr median value; In the control group, 101.7 µg/L (91.3-170.2); In stage 3-4 CKD patients, 102.1 µg/L (82.3-140.2); In HD patients, 147.2 µg/L (101.95-191.65); In PD patients, 112.1 µg/L (92.3-132.1) was detected. Crom level was found higher in HD group, but this difference wasn’t significant (p=0.458). There was no significant difference between the groups in serum Zn, Ni, Se, Mn, Pb and Cd levels.

Conclusions:

In the evaluation of eser elements, it was determined that only Cu level was low in the patients. Although Cr level, which is one of the toxic trace elements, is higher in HD patients compared to other groups, a statistically significant level could not be determined. We believe that, multicenter studies with more patients and control groups are needed on this subject.