ESPN 54th Annual Meeting

ESPN 2022


 
RELATIONSHIP OF CIRCULATING IRISIN WITH BODY COMPOSITION IN CHILDREN WITH CHRONIC KIDNEY DISEASE
EMRE CEYHUN 1 SEHA SAYGILI 2 SERGEN DEVRAN 3 RÜVEYDA GÜLMEZ 2 KAAN CAN DEMİRTAŞ 4 ŞEVVAL ÇELEN 5 AYŞE AĞBAŞ 2 SALİM ÇALIŞKAN 2 BÜLENT BAYRAKTAR 3 NUR CANPOLAT 2

1- 1. Istanbul University – Cerrahpasa, Cerrahpasa Medical Faculty, Department of Pediatrics
2- 2. Istanbul University – Cerrahpasa, Cerrahpasa Medical Faculty, Department of Pediatric Nephrology
3- 3. Istanbul University, Faculty of Medicine, Sports Medicine Department
4- 4. Istanbul University – Cerrahpasa, Cerrahpasa Medical Faculty
5- 5. Istanbul University, Faculty of Sports Science
 
Introduction:

Children with chronic kidney disease (CKD) suffer from decreased exercise capacity due to the uremic environment, protein-energy-wasting, oxidative stress, and inflammation. Low levels of irisin, a recently discovered exercise-induced myokine, have been linked to adverse metabolic outcomes. The aim of this study was to evaluate the serum irisin levels in children with CKD and to analyze its potential associations with body composition, estimated glomerular filtration rate (eGFR), markers of oxidative stress, and inflammation.

Material and methods:

This cross-sectional, single-center study enrolled 39 children with CKD (22 male, aged 7.7 to 20.7 years, 26 children CKD stage 3 and 4 and 13 CKD 5D) and age and gender compatible 29 healthy children. Standard deviation scores (SDS) of height and body mass index (BMI) for height age were calculated according to national percentiles. Body composition parameters were measured with the multiple-frequency bioimpedance device. Serum concentrations of irisin, CRP, TNF-alpha, total antioxidant capacity (TAS), and total oxidant capacity (TOS) were analyzed by ELISA assays.

Results:

 The number of underweight, overweight, and obese children in the CKD group was 4 (10.3%), 5 (12.8%), and 7 (17.9%), respectively. Although there were no differences in BMI-SDS or body composition parameters between the patient and control groups, median serum irisin level was lower in the CKD group than in the control group (3.97 vs 4.54 ng/ml, p= 0.03). However, there was no difference in irisin levels between patients with CKD 3-4 and CKD 5D. Serum irisin levels showed no association with BMI-SDS, body composition parameters, eGFR, CRP, TNF-alpha, TAS, TOS, or serum lipid levels.

Conclusions:

 

This study demonstrates decreased serum irisin concentrations in pediatric CKD patients. However, there is no association of irisin with any body composition parameters, inflammatory or oxidative stress markers. Further studies are needed to investigate the factors affecting serum irisin levels in children with CKD.